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David Glover

Research Professor of Biology and Biological Engineering
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B.A., University of Cambridge, 1969; Ph.D., University College (London), 1972. Caltech, 2019-.
Phone: 626-395-2341
Office: 133B Beckman Institute
Mail Code: MC 139-74
link Research Website

Research Areas

Biochemistry, Structural, and Molecular Cell Biology;  Developmental Biology and Genetics; 
Research Summary
Mitosis assembly and function of macromolecular machines.
Profile

David is a preeminent cell biologist with a history of landmark discoveries of the molecular mechanisms underlying mitosis (i.e., cell division). His work focuses on early steps in mitosis that involve the assembly and function of the macromolecular machines responsible for cell division. Dr. Glover has also had a distinguished career in community service as a journal editor and science advisor. His honors include election to the Royal Society in 2009. David received his undergraduate degree from the University of Cambridge, and his doctorate from University College (London).

  1. Kovacs, J. Chao-Chu, S. Schneider, N.S. Dzhindzhev, A. Gottardo, M.G. Riparbelli, G. Callaini and D.M. Glover (2018) Dual requirement for the golgin GORAB at the Golgi and for the structure and duplication of centrioles. Nat Genet. 2018 Jul;50(7):1021-1031. doi: 10.1038/s41588-018-0149-1.
  2. Dzhindzhev NS, Tzolovsky G, Lipinszki Z, Schneider S, Lattao R, Fu J, Debski J, Dadlez M, Glover DM. (2014) Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation. Curr Biol. pii: S0960-9822(14)01074-4. doi: 10.1016/j.cub.2014.08.061.
  3. Coelho, P.A., Bury, L., Fu, J., Sharif, B., Riparbelli, M.G., Callaini, G., Glover, D.M. and Zernicka-Goetz, M. (2013) Acentriolar spindle formation in the early mouse embryo requires the "centriolar" protein kinase, Plk4 Dev. Cell 27:586-97
  4. Rangone, H., Wegel, E., Gatt, M.K., Yeung, E., Flowers, A., Debski, J., Dadlez, M., Janssens, V., Carpenter, A.T.C., and Glover, D.M. (2011) Suppression of Scant Identifies Endos as a Substrate of Greatwall Kinase and a Negative Regulator of Protein Phosphatase 2A in Mitosis PLoS Genet. 2011 Aug;7(8):e1002225.
  5. Dzhindzhev, N., Yu, Q.D., Weiskopf, K., Cunha-Ferreira, I., Riparbelli, M., Rodrigues-Martins, A., Bettencourt-Dias, M., Callaini, G., and Glover, D.M. (2010) Asterless provides a molecular platform for centriole assembly – Nature 467, 714-718
  6. Rodrigues-Martins, A., Riparbelli, M., Callaini, G., Glover, D.M., and Bettencourt-Dias, M. (2007) Revisiting the Role of the Mother Centriole in Centriole Biogenesis Science 316: 1046-1-50
  7. Bettencourt-Dias, M., Martins, A., Carpenter, L., Riparbelli, M., Gatt, M., Lehmann, L., Carmo, N., Balloux, F., Callaini, G., and Glover, D.M. (2005) SAK/PLK4 is necessary for centriole replication Current Biol. 15: 2199-207.
  8. Bettencourt Dias, M., Giet, R., Sinka, R., Mazumdar, A., Lock, W.G., Balloux, F., Zafiropoulos, P.J., Yamaguchi, S., Winter, S., Carthew, R.W., Cooper, M., Frenz, L. and Glover, D.M. (2004) Genome-wide survey of protein kinases required for cell cycle progression. Nature.432: 980-7.
  9. Mayer-Jaekel RE, Ohkura H, Gomes R, Sunkel CE, Baumgartner S, Hemmings BA and Glover DM (1993). The 55kD regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Cell 72: 621-634.
  10. Alphey L, Jimenez J, White-Cooper H, Dawson I, Nurse P and Glover DM (1992). twine, a cdc25 homologue that functions in the male and female germ-line of Drosophila. Cell 69: 977-988.
  11. Llamazares S, Moreira MA, Tavares A, Girdham C, Gonzalez C, Karess RE, Glover DM and Sunkel CE (1991). polo encodes a protein kinase homologue required for mitosis in Drosophila. Genes and Dev 5: 2153-2164.
  12. Giet, R., and Glover, D.M. (2001) Drosophila Aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organise the central spindle during cytokinesis J. Cell Biol. 152: 669-682
  13. Avides, M.C., and Glover, D.M. (1999) Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal organising centers. Science 283: 1733-1735
  14. Ohkura H, Hagan I and Glover DM (1995). The conserved S. pombe kinase plo1+, required to establish a bipolar spindle, actin ring and septum formation, can promote septum formation in G1 and G2 cells. Genes and Dev 9: 1059-1073.
  15. Glover DM, Leibowitz MH, McLean D and Parry H (1995). Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81: 95-105.
  16. Fenton B and Glover DM (1993). polo, a conserved mitotic kinase, is active at late anaphase-telophase in the syncytial Drosophila embryo. Nature 363: 637-639.
  17. Sunkel C and Glover DM (1988) polo: a mitotic mutant of Drosophila displaying abnormal spindle poles. J. Cell. Sci. 89: 25-38.